Why the study?
Are elevated Lp(a) levels and altered plasminogen activity associated with specific etiologies of ischemic stroke?
Population
253 consecutive patients with acute ischemic stroke and 63 controls
Comparison
Elevated Lp(a) levels and plasminogen activity vs Controls and different stroke subtypes
Design
Case-control
Authors
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Elevated Lp(a) associated with large-artery atherosclerotic stroke; hypothesis-generating and requires prospective confirmation before clinical use.
Are elevated Lp(a) levels and altered plasminogen activity associated with specific etiologies of ischemic stroke?
Elevated Lp(a) is associated with ischemic stroke, particularly those caused by large artery atherosclerosis, while low plasminogen activity may play a role in cardioembolic stroke.
Petersen et al. (2006) studied this question.
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