What question did this study set out to answer?

To investigate whether specific Lactobacillus peptidoglycans and derived muropeptides protect against experimental colitis through NOD2-dependent immune signaling.

April 6, 2011Gut

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

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To investigate whether specific Lactobacillus peptidoglycans and derived muropeptides protect against experimental colitis through NOD2-dependent immune signaling.
Induced colitis in wild-type, Nod2-deficient, MyD88-deficient, and Il10-deficient mice using 2,4,6-trinitrobenzene sulfonic acid (TNBS).
Administered Lactobacillus salivarius Ls33, purified peptidoglycans, or synthetic muropeptides, and measured CD103(+) dendritic cells, regulatory T cells, and adoptive transfer responses.
Identified and characterized peptidoglycan structural differences between bacterial strains using high-performance liquid chromatography and mass spectrometry.
Peptidoglycan from Lactobacillus salivarius Ls33 protected mice from colitis by inducing interleukin-10, CD103(+) dendritic cells, and CD4(+)Foxp3(+) regulatory T cells in a NOD2-dependent manner.
Structural analysis identified a unique muropeptide (M-tri-Lys) in Ls33 whose synthetic counterpart rescued mice from colitis via NOD2 signaling independent of MyD88.

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Implication

Animal study reveals that a specific Lactobacillus muropeptide reduces intestinal inflammation in mice with colitis, indicating a potential targeted approach for inflammatory bowel disease.

Cite This Study

Fernandez et al. (2011) studied this question.

synapsesocial.com/papers/6a1bc910ea84844e355ef4c3 https://doi.org/10.1136/gut.2010.232918

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Implication

Animal study reveals that a specific Lactobacillus muropeptide reduces intestinal inflammation in mice with colitis, indicating a potential targeted approach for inflammatory bowel disease.

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Key Points

Discussion

Implication

Cite This Study

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Key Points

Discussion

Implication

Cite This Study

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