What does this research mean for the field?

In patients with cardiac sarcoidosis and mildly impaired cardiac function (LVEF > 35%), concomitant nonsustained ventricular tachycardia with atrioventricular block or abnormal Ga/PET imaging independently predict ventricular arrhythmic events, indicating that ICDs should be considered for primary prevention in this population. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 5, 2023JACC AsiaOpen Access

Fatal Arrhythmic Risks in Cardiac Sarcoidosis With Mildly Impaired Cardiac Function

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Why the study?

The prognosis and risk of later fatal arrhythmia in cardiac sarcoidosis with relatively preserved cardiac function were unclear.

What are the predictors of ventricular arrhythmic events in patients with cardiac sarcoidosis and mildly impaired cardiac function (LVEF >35%)?

Population

322 patients with cardiac sarcoidosis and LVEF >35% from 57 Japanese hospitals

Comparison

Patients with VT manifestation vs without VT manifestation

Design

Multicenter nationwide cohort survey

Follow-up

Median of 5 years

Authors

HKHiroyuki Kamada KIKohei Ishibashi YMYuichiro Miyazaki

Discussion

Member takes

Overview

May refine arrhythmic risk stratification in cardiac sarcoidosis; leaves open whether predictors warrant primary prevention ICDs in LVEF >35%.

Structured PICO

What are the predictors of ventricular arrhythmic events in patients with cardiac sarcoidosis and mildly impaired cardiac function (LVEF >35%)?

Population

322 patients with cardiac sarcoidosis (CS) and mildly impaired cardiac function (LVEF >35%) from a nationwide Japanese cohort survey across 57 hospitals.

Outcome

All-cause death and ventricular arrhythmic events (VAEs, including sudden cardiac death and appropriate ICD discharges) over a median of 5 years.hard clinical

In patients with cardiac sarcoidosis and LVEF >35%, primary prevention ICD should be considered if they have concomitant NSVT with AVB or abnormal Ga/PET due to a significant risk of fatal arrhythmias.

Cite This Study

Kamada et al. (2023) studied this question.

synapsesocial.com/papers/6a1bc92d4ebd09f3dfa901cf https://doi.org/10.1016/j.jacasi.2023.07.006

View Full Paper

Ask AI

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September 5, 2023JACC AsiaOpen Access

Fatal Arrhythmic Risks in Cardiac Sarcoidosis With Mildly Impaired Cardiac Function

View Full Paper

Ask AI

Bookmark

Why the study?

The prognosis and risk of later fatal arrhythmia in cardiac sarcoidosis with relatively preserved cardiac function were unclear.

What are the predictors of ventricular arrhythmic events in patients with cardiac sarcoidosis and mildly impaired cardiac function (LVEF >35%)?

Population

322 patients with cardiac sarcoidosis and LVEF >35% from 57 Japanese hospitals

Comparison

Patients with VT manifestation vs without VT manifestation

Design

Multicenter nationwide cohort survey

Follow-up

Median of 5 years

Authors

HKHiroyuki Kamada KIKohei Ishibashi YMYuichiro Miyazaki

Discussion

Member takes

Overview

May refine arrhythmic risk stratification in cardiac sarcoidosis; leaves open whether predictors warrant primary prevention ICDs in LVEF >35%.

Structured PICO

What are the predictors of ventricular arrhythmic events in patients with cardiac sarcoidosis and mildly impaired cardiac function (LVEF >35%)?

Population

322 patients with cardiac sarcoidosis (CS) and mildly impaired cardiac function (LVEF >35%) from a nationwide Japanese cohort survey across 57 hospitals.

Outcome

All-cause death and ventricular arrhythmic events (VAEs, including sudden cardiac death and appropriate ICD discharges) over a median of 5 years.hard clinical

Cite This Study

Kamada et al. (2023) studied this question.

synapsesocial.com/papers/6a1bc92d4ebd09f3dfa901cf https://doi.org/10.1016/j.jacasi.2023.07.006

View Full Paper

Ask AI

Bookmark