Image formation in diffusion MRI: A review of recent technical developments

Diffusion magnetic resonance imaging (MRI) is a standard imaging tool in clinical neurology, and is becoming increasingly important for neuroscience studies due to its ability to depict complex neuroanatomy (eg, white matter connectivity). Single-shot echo-planar imaging is currently the predominant formation method for diffusion MRI, but suffers from blurring, distortion, and low spatial resolution. A number of methods have been proposed to address these limitations and improve diffusion MRI acquisition. Here, the recent technical developments for image formation in diffusion MRI are reviewed. We discuss three areas of advance in diffusion MRI: improving image fidelity, accelerating acquisition, and increasing the signal-to-noise ratio. LEVEL OF EVIDENCE: 5 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:646-662.