Why the study?
Correlates of protection are primarily based on serum neutralizing antibody concentrations due to difficulty assaying complex T-cell interactions, highlighting the need for a more comprehensive understanding of susceptibility and cellular contributions.
Key points are not available for this paper at this time.
Design
Review paper
Highlights the need for a more comprehensive understanding of cellular immunity beyond serum neutralizing antibodies to assess viral protection.
Validated, reproducible methods to assess immunity to a specific virus following either infection or vaccination are important for understanding susceptibility to existing and emerging infectious diseases. Correlates of protection for a specific viral illness involve humoral and cellular responses that differ by pathogen and by the portal of entry into the host. Contemporary understanding of a correlate of protection primarily is based on serum neutralizing antibody concentrations because of difficulty in assaying the complex interactions of T cells. A more comprehensive understanding of susceptibility and protection is needed. The goal of this paper is to enumerate the multiple variables that complicate understanding of cellular contributions to the innate and adaptive immune responses.
No takes yet. Share an insight, caveat, or question.
Meissner et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: