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July 1, 1992Circulation Research

Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy.

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Population

38 human hearts from patients undergoing cardiac transplantation, including normal and cardiomyopathic.

Design

Cross-sectional

Authors

ABA M BrillantesAmerican Diabetes AssociationPAPaul D. AllenElectrophysiologyTTToshiyuki TakahashiKanazawa University

Discussion

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Implication

Decreased CRC mRNA in ischemic cardiomyopathy suggests etiology-specific calcium handling defects; hypothesis-generating, should not yet change practice.

Structured PICO

P
Population
38 human hearts from patients undergoing cardiac transplantation, including normal (n=4) and cardiomyopathic (n=34; 18 ischemic, 14 idiopathic dilated).
C
Comparator
Normal human hearts (n=4)
O
Outcome
Calcium release channel (CRC) mRNA levels in the left ventriclessurrogate

CRC mRNA expression is significantly decreased in end-stage ischemic cardiomyopathy but not in idiopathic dilated cardiomyopathy, suggesting different molecular mechanisms of calcium handling dysfunction.

Cite This Study

Brillantes et al. (1992) studied this question.

synapsesocial.com/papers/6a1bcbbab33628da419ce00ehttps://doi.org/10.1161/01.res.71.1.18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inotropic and lusitropic abnormalities in the genesis of heart failure1983 · 40 citations
  2. 2Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.1990 · 630 citations
  3. 3The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family1982 · 181 citations
  4. 4Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.1989 · 289 citations
  5. 5Abnormal Intracellular Modulation of Calcium as a Major Cause of Cardiac Contractile Dysfunction1991 · 313 citations