Why the study?
Does pharmacological block of Na/Ca exchange (NCX) improve contractile function and reduce arrhythmias in cardiac hypertrophy and heart failure?
Does pharmacological block of Na/Ca exchange (NCX) improve contractile function and reduce arrhythmias in cardiac hypertrophy and heart failure?
Pharmacological targeting of the Na/Ca exchanger in heart failure and hypertrophy may offer therapeutic benefits in specific conditions, particularly if specific modes of the exchanger can be targeted.
No takes yet. Share an insight, caveat, or question.
NCX blockade merits targeted investigation only; leaves open which remodeling states may benefit from selective inhibition.
Karin R. Sipido (2002) studied this question.
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