What does this research mean for the field?

Overexpression of the Na+/Ca2+-exchanger in failing myocardium compensates for downregulated SERCA by enhancing Ca2+ efflux to improve diastolic relaxation and facilitating Ca2+ reuptake by SERCA to restore sarcoplasmic reticulum Ca2+ load. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 1, 2001Cardiovascular Research

How can overexpression of Na+,Ca2+-exchanger compensate the negative inotropic effects of downregulated SERCA?

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Structured PICO

Population

Ventricular myocytes from transgenic mice (TR) overexpressing the Na+/Ca2+-exchanger and non-transgenic (non-TR) wild-type littermates

Intervention

Overexpression of the Na+/Ca2+-exchanger

Comparator

Non-transgenic (non-TR) wild-type littermates

Outcome

Protein concentrations and functions of Ca2+ handling proteinssurrogate

Discussion

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Implication

This editorial highlights findings that enhanced expression of the Na+/Ca2+-exchanger may facilitate Ca2+ reuptake by SERCA and compensate for impaired SR Ca2+ load in failing myocardium.

Cite This Study

G Isenberg (2001) studied this question.

synapsesocial.com/papers/6a1bccf926cb5670aa9cea70 https://doi.org/10.1016/s0008-6363(00)00284-4

Topics

Heart failure HFrEF treatment

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Implication

This editorial highlights findings that enhanced expression of the Na+/Ca2+-exchanger may facilitate Ca2+ reuptake by SERCA and compensate for impaired SR Ca2+ load in failing myocardium.