What does this research mean for the field?

A 4-AP-sensitive rapid delayed rectifier K+ current regulates repolarization in the adult mouse ventricle, and its blockade significantly enhances cardiac contractility by prolonging action potential duration. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1997The Journal of PhysiologyOpen Access

A rapidly activating sustained K+ current modulates repolarization and excitation–contraction coupling in adult mouse ventricle

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Why the study?

Does 4-aminopyridine modulate repolarization and excitation-contraction coupling in adult mouse ventricle?

Population

Adult mouse ventricle (single cell preparations and in vitro working heart preparation)

Comparison

4-aminopyridine at concentrations between 3 and… vs Baseline/control conditions without 4-AP

Design

Preclinical

Authors

CFCéline FisetMontreal Heart Institute RCRobert B. ClarkGovernment of the United States of America TLTerje S. LarsenCalanus (Norway)

Discussion

Member takes

Implication

Kv1.5 blockade enhances murine ventricular contractility; hypothesis-generating for human repolarization-targeted therapies.

Structured PICO

Does 4-aminopyridine modulate repolarization and excitation-contraction coupling in adult mouse ventricle?

Population

Adult mouse ventricle (single cell preparations and in vitro working heart preparation)

Intervention

4-aminopyridine (4-AP) at concentrations between 3 and 200 microM

Comparator

Baseline/control conditions without 4-AP

Outcome

Action potential duration, sustained K+ current at plateau potentials, and left ventricular systolic pressuresurrogate

The 4-AP-sensitive rapid delayed rectifier (Kv1.5) is a crucial repolarizing current in adult mouse ventricle, and its blockade significantly enhances contractility.

Cite This Study

Fiset et al. (1997) studied this question.

synapsesocial.com/papers/6a1bccfc26cb5670aa9cea79 https://doi.org/10.1111/j.1469-7793.1997.557bd.x

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A rapidly activating sustained K+ current modulates repolarization and excitation–contraction coupling in adult mouse ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A rapidly activating sustained K+ current modulates repolarization and excitation–contraction coupling in adult mouse ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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