Population
Transgenic mice overexpressing cardiac Na(+)-Ca2+ exchange activity (isolated ventricular myocytes)
Comparison
Overexpression of cardiac Na(+)-Ca2+ exchanger vs Control myocytes
Design
Preclinical
Authors
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NCX overexpression leaves SR Ca2+ content and release intact in mice; leaves open microdomain exclusion in human cardiomyocytes.
The Na+-Ca2+ exchanger remains functionally excluded from the Ca2+ microdomains surrounding the DHP/ryanodine receptor complex in transgenic mice overexpressing the exchanger.
Adachi‐Akahane et al. (1997) studied this question.
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