Continuous Generation of NADH from NAD⊕ and Formate Using a Homogeneous Catalyst with Enhanced Molecular Weight in a Membrane Reactor

Bonding the Rh III complex 1 to polyethylene glycol (MW 20 000) leads to a high molecular weight redox catalyst suitable for continuous generation of the cofactors NADH and NADPH. With the aid of a newly designed flow‐through membrane reactor it has proven possible to achieve an NAD ⊕ conversion of 40–45% (turnover number 16.9 h −1 , space‐time yield 44.3mmol L −1 d −1 ). Since the reactivity towards polyethylene glycol‐bound NAD ⊕ remains constant, this catalyst is also suited to use in a continuously operating enzyme‐membrane reactor. equation image