Genetics in cardiovascular diseases
Why the study?
The probabilistic nature of genetic testing and subjectivity of variant classification make clinical application of genetics difficult in precision diagnostics and therapeutics.
What is the role of next generation sequencing in the clinical diagnosis and risk assessment of cardiovascular diseases?
Design
Systematic review
Authors
Discussion
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Member takes
Implication
Advocates multidisciplinary cardio-genetic centers for NGS use; extends Level 1 evidence supporting precision diagnostics in cardiovascular disease.
Structured PICO
What is the role of next generation sequencing in the clinical diagnosis and risk assessment of cardiovascular diseases?
P
Population
Individuals with cardiovascular diseases (CVDs) including coronary artery, valve, pericardial, conduction system, myocardial and vascular diseases, and family members at risk
I
Intervention
Next generation sequencing (NGS) / genetic testing
O
Outcome
Clinical diagnosis and risk assessment
This systematic review highlights the growing importance of next-generation sequencing in cardiovascular precision medicine while emphasizing the need for specialized multidisciplinary centers to handle the complexities of genetic variant interpretation.
Cite This Study
Celeghin et al. (2019) studied this question.