What does this research mean for the field?

In human cardiac hypertrophy, the ectopic expression of the atrial myosin essential light chain (ALC1) in the ventricle partially replaces the ventricular isoform (VLC1), resulting in faster cross-bridge kinetics, higher Ca(2+)-sensitivity, and an increased duty ratio that can be either beneficial or detrimental depending on the state of the cardiomyocyte. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1998Cardiovascular ResearchOpen Access

Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms

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Population

Human cardiac hypertrophy (molecular/cellular level)

Design

Review

Authors

MSMarcus SchaubSwiss Federal Institute for Forest, Snow and Landscape Research MHMartin A. HeftiUniversity of Zurich RZRichard A. ZuelligUniversity of Zurich

Discussion

Member takes

Implication

May modulate contractility in hypertrophy; supports isoform insights but leaves open clinical relevance.

Structured PICO

Population

Human cardiac hypertrophy (molecular/cellular level)

This review highlights how changes in myosin essential light chain isoforms and sarcomeric protein phosphorylation modulate contractility in human cardiac hypertrophy.

Cite This Study

Schaub et al. (1998) studied this question.

synapsesocial.com/papers/6a1bcd690a1f7575939cf2aa https://doi.org/10.1016/s0008-6363(97)00258-7

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February 1, 1998Cardiovascular ResearchOpen Access

Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms

View Full Paper

Ask AI

Bookmark

Population

Human cardiac hypertrophy (molecular/cellular level)

Design

Review

Authors

MSMarcus SchaubSwiss Federal Institute for Forest, Snow and Landscape Research MHMartin A. HeftiUniversity of Zurich RZRichard A. ZuelligUniversity of Zurich

Discussion

Member takes

Implication

May modulate contractility in hypertrophy; supports isoform insights but leaves open clinical relevance.

Structured PICO

Population

Human cardiac hypertrophy (molecular/cellular level)

This review highlights how changes in myosin essential light chain isoforms and sarcomeric protein phosphorylation modulate contractility in human cardiac hypertrophy.

Cite This Study

Schaub et al. (1998) studied this question.

synapsesocial.com/papers/6a1bcd690a1f7575939cf2aa https://doi.org/10.1016/s0008-6363(97)00258-7

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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