What does this research mean for the field?

The potassium channel isoform Kv1.3, but not Kv3.1, is capable of reconstituting regulatory volume decrease (RVD) in T lymphocytes, a function that depends critically on the specific voltage-dependent activation properties of the channel. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1993Proceedings of the National Academy of SciencesOpen Access

Heterologous expression of specific K+ channels in T lymphocytes: functional consequences for volume regulation.

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Population

Mouse cytotoxic T-lymphocyte line (CTLL-2) devoid of voltage-dependent K+ channels

Comparison

Transient transfection with K+ channel isoforms… vs Untransfected CTLL-2 cells

Design

Preclinical

Authors

CDCarol DeutschCalifornia University of Pennsylvania LCL Q ChenUniversity of Pennsylvania

Discussion

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Implication

Cell-line data on Kv1.3-specific volume regulation should not change practice; extends isoform-specific RVD model for targeted human studies.

Structured PICO

Population

Mouse cytotoxic T-lymphocyte line (CTLL-2) devoid of voltage-dependent K+ channels

Intervention

Transient transfection with K+ channel isoforms Kv1.3 or Kv3.1

Comparator

Untransfected CTLL-2 cells

Outcome

Regulatory volume decrease (RVD) in response to hypotonic shocksurrogate

The Kv1.3 potassium channel isoform specifically enables regulatory volume decrease in T-lymphocytes, dependent on its voltage activation characteristics.

Cite This Study

Deutsch et al. (1993) studied this question.

synapsesocial.com/papers/6a1bcda31567d2fc4d5f08f5 https://doi.org/10.1073/pnas.90.21.10036

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Implication

Cell-line data on Kv1.3-specific volume regulation should not change practice; extends isoform-specific RVD model for targeted human studies.

Heterologous expression of specific K+ channels in T lymphocytes: functional consequences for volume regulation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heterologous expression of specific K+ channels in T lymphocytes: functional consequences for volume regulation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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