Why the study?
Does experimentally induced hypoglycemia alter brain glutamate concentration in T1D patients with HAAF compared to those without HAAF and healthy controls?
Population
15 subjects: Type 1 diabetes patients with hypoglycemia-associated autonomic failure, T1D patients without…
Comparison
Experimentally induced hypoglycemia via… vs T1D patients without HAAF and healthy controls…
Design
Other
Authors
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May indicate metabolic adaptation in HAAF; leaves open glutamate's role in hypoglycemia awareness.
Does experimentally induced hypoglycemia alter brain glutamate concentration in T1D patients with HAAF compared to those without HAAF and healthy controls?
The lack of significant decrease in brain glutamate during hypoglycemia in T1D patients with HAAF suggests a metabolic adaptation providing alternative fuels to the brain.
Terpstra et al. (2014) studied this question.
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