Key result
Type 1 diabetes patients with hypoglycemia unawareness displayed a blunted physiologic increase in thalamic cerebral blood flow during moderate hypoglycemia compared to healthy controls.
Why the study?
Does hypoglycemia unawareness in type 1 diabetes blunt the thalamic cerebral blood flow increase during moderate hypoglycemia compared to healthy controls?
Population
23 subjects total: 11 patients with well-controlled type 1 diabetes and hypoglycemia unawareness and 12…
Comparison
Two-step hyperinsulinemic clamp with blood… vs Healthy controls undergoing the same…
Design
Case-control
Authors
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Blunted thalamic CBF response may underlie hypoglycemia unawareness; hypothesis-generating and should not yet change practice.
Observational (n=23)
Does hypoglycemia unawareness in type 1 diabetes blunt the thalamic cerebral blood flow increase during moderate hypoglycemia compared to healthy controls?
Patients with type 1 diabetes and hypoglycemia unawareness have a blunted thalamic cerebral blood flow response to hypoglycemia, which correlates with a reduced epinephrine response.
Mangia et al. (2012) conducted an observational in Type 1 Diabetes and Hypoglycemia Unawareness (n=23). Type 1 diabetes with hypoglycemia unawareness vs. Healthy controls was evaluated on Thalamic cerebral blood flow (CBF) increase during the early phase of moderate hypoglycemia. Type 1 diabetes patients with hypoglycemia unawareness displayed a blunted physiologic increase in thalamic cerebral blood flow during moderate hypoglycemia compared to healthy controls.
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