Key result
Hypoglycemia unawareness in type 1 diabetes was associated with attenuated FDG uptake in the left amygdala during hypoglycemia compared to patients with awareness (-0.40 vs 3.66; P=0.007).
Why the study?
Does hypoglycemia unawareness alter regional brain glucose kinetics during hypoglycemia in men with type 1 diabetes?
Population
13 men with type 1 diabetes (6 with hypoglycemia awareness and 7 with hypoglycemia unawareness)
Comparison
Hypoglycemia (2.6 mmol/l) vs Euglycemia (5 mmol/l)
Design
Other, Conditions were administered in random order
Authors
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Altered brain glucose metabolism seen in unawareness; leaves open causal mechanisms and clinical relevance.
Observational (n=13)
random order
Does hypoglycemia unawareness alter regional brain glucose kinetics during hypoglycemia in men with type 1 diabetes?
Absolute Event Rate: -0.4% vs 3.66%
p-value: p=0.007
Hypoglycemia unawareness in type 1 diabetes is associated with attenuated amygdala and orbitofrontal cortex responses to low blood glucose, suggesting habituation of behavioral responses.
Dunn et al. (2007) conducted an observational in Type 1 diabetes (n=13). Hypoglycemia unawareness vs. Hypoglycemia awareness was evaluated on FDG uptake in left amygdala during hypoglycemia (p=0.007). Hypoglycemia unawareness in type 1 diabetes was associated with attenuated FDG uptake in the left amygdala during hypoglycemia compared to patients with awareness (-0.40 vs 3.66; P=0.007).
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