Why the study?
What are the clinical characteristics and physiological responses associated with hypoglycemia unawareness in patients with IDDM?
Population
43 patients with insulin-dependent diabetes mellitus (IDDM)
Comparison
Stepped hypoglycemic clamp technique vs Patients without hypoglycemia unawareness
Design
Cross-sectional
Authors
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Hypoglycemia unawareness was associated with lower HbA1c and longer diabetes duration; leaves open causal direction and prospective validation in IDDM.
What are the clinical characteristics and physiological responses associated with hypoglycemia unawareness in patients with IDDM?
Hypoglycemia unawareness in IDDM is associated with longer disease duration, lower HbA1c, history of severe hypoglycemia, and increased insulin sensitivity.
Mokáň et al. (1994) studied this question.
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