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June 27, 2025Open Access

Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity

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Why the study?

Doxorubicin is an effective chemotherapy limited by cardiotoxicity, prompting investigation into its underlying mechanisms.

Population

Five-week-old male mice and DOX-treated breast cancer patients

Comparison

Weekly DOX (4 mg/kg) vs saline injections

Design

Preclinical multi-omics study integrating transcriptomic and proteomic profiling with patient validation

Follow-up

4 days and 6 weeks post-DOX

Authors

MDMohamed S. DabourIAIbrahim Y. AbdelgawadBSBushra Sadaf

Discussion

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Member takes

Overview

SERPINA3 merits evaluation as a translational biomarker for doxorubicin cardiotoxicity; leaves open validation and clinical utility in prospective human studies.

Structured PICO

P
Population
Five-week-old male mice (established mouse models of chronic DOX-induced cardiotoxicity) and DOX-treated breast cancer patients
I
Intervention
Doxorubicin (4 mg/kg weekly for six weeks)
C
Comparator
Saline injections
O
Outcome
Differentially expressed genes (DEGs) and proteins (DEPs) in heart tissues 4 days post-treatmentsurrogate

A multi-omics approach in a mouse model of doxorubicin-induced cardiotoxicity identified dynamic temporal changes in molecular pathways and highlighted SERPINA3 as a potential translational biomarker.

Cite This Study

Dabour et al. (2025) studied this question.

synapsesocial.com/papers/6a1bcf8b26cb5670aa9ceff4https://doi.org/10.1101/2025.06.24.661365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integration of transcriptomics, metabolomics, and lipidomics reveals the mechanisms of doxorubicin-induced inflammatory responses and myocardial dysfunction in mice2023 · 24 citations
  2. 2Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity2025 · 3 citations
  3. 3Transcriptomic profiling reveals p53 as a key regulator of doxorubicin-induced cardiotoxicity2019 · 89 citations
  4. 4Characterization of systolic and diastolic function, alongside proteomic profiling, in doxorubicin-induced cardiovascular toxicity in mice2024 · 17 citations
  5. 5Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity2024 · 5 citations