Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model

• There is demonstrated upregulated neuroinflammatory and oxidative stress-related hippocampal responses following wood smoke exposure within a diminished ovarian-hormone state. • Acute wood smoke exposure is linked to hippocampal cell-type-specific transcriptional changes • Neuronal and glial populations exhibit distinct synaptic and immune pathway patterns following wood smoke exposure in an accelerated ovarian failure model.