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June 14, 2026Particle and Fibre ToxicologyOpen Access

Bronchial mucosal nuclear transcription factor expression and inflammatory response in humans after exposure to wood smoke

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Authors

AHAlva HanssonUmeå UniversityMFMaria FribergUmeå UniversityGRGregory RankinUmeå University

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Overview

Randomized trial investigates inflammatory response in healthy individuals exposed to wood smoke, highlighting potential respiratory health risks.

Key Points

  • The study aims to evaluate the acute inflammatory response in bronchial mucosal biopsies after exposure to wood smoke.
  • Fourteen healthy participants underwent double-blind, randomised crossover exposure to filtered air and wood smoke.
  • Participants were exposed for 2 hours to diluted wood smoke with a particulate matter concentration of 409 ± 43 µg/m3.
  • Bronchoscopy was performed to sample endobronchial mucosal biopsies and lavage fluids 6 hours post-exposure.
  • Nuclear translocation of aryl hydrocarbon receptor and phosphorylated c-jun significantly reduced in bronchial biopsies after wood smoke exposure.
  • No recruitment of neutrophils or inflammatory cells was observed in the bronchial mucosa post exposure.
  • The findings suggest a suppression of expected inflammatory responses compared to other pollutants.

Cite This Study

Hansson et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8ca72https://doi.org/10.1186/s12989-026-00685-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats2024 · 4 citations
  2. 2Temporal variation in markers of immune signaling and wound repair in primary human airway epithelial cells following acute vs. repeated woodsmoke condensate exposure2026
  3. 3Monitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air–liquid interface2024 · 9 citations
  4. 4B79-14 Functional-immunological Changes in the Lungs of Apoe-/- Mice Following Repeated Exposure to Flaming Eucalyptus-Manzanita Smoke2026
  5. 547 Wildfire surrogate wood smoke particles elicit events linked to premalignant effects in human lung epithelial cells2026