Long-term spatial memory, anxiety-like behavior and oxidative stress markers in an adolescent binge-alcohol model: Evaluation of DHA as a potential protective agent

Key Points

• This research evaluates the long-term impacts of binge alcohol on spatial memory and anxiety in adolescents, and the potential protective role of DHA.
• Adolescent animals were exposed to binge-like ethanol (EtOH), followed by assessment of spatial memory deficits.
• DHA treatment was administered to evaluate its protective effects on memory and oxidative stress markers.
• Anxiety-like behavior was assessed in relation to oxidative stress markers.
• DHA partially reduced the detrimental effects of EtOH on spatial memory.
• DHA decreased catalase (CAT) activity in the prefrontal cortex (PFC) and ventral tegmental area (VTA).
• Oxidative stress markers showed a positive correlation with anxiety-like behavior in EtOH-treated animals.