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May 31, 2026Global Pediatrics0 citationsOpen Access

Shaping Minds: Family Environmental Influences on Early Neurodevelopment

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ELErika LoiSMSerena MichelettiJGJessica Galli

Key Points

  • This review aims to synthesize evidence on how family environments affect neurodevelopmental outcomes in children.
  • Examined key domains of family environment as protective or vulnerable factors in child neurodevelopment.
  • Focused on structural and relational dimensions affecting brain maturation.
  • Highlighted the interplay of environmental factors and their implications for therapeutic interventions.
  • Identified family structural factors like socioeconomic status impact neurodevelopmental trajectories.
  • Highlighted the importance of emotional regulation and caregiving in fostering healthy early experiences.
  • Sought to inform future preventive approaches to mitigate risk for neurodevelopmental disorders.

Abstract

Neurodevelopment arises from the complex interplay of genetic, epigenetic, neurobiological, environmental, and experiential factors that shape the maturation of brain and adaptive functions. Early experiences, particularly within sensitive developmental periods, can either support or disrupt these processes, influencing vulnerability to neurodevelopmental disorders. Among early environmental determinants, family represents the most proximal and dynamic context for the developing child, providing the primary sources of stimulation, emotional regulation, and caregiving. The family environment encompasses both structural (e.g., socioeconomic conditions) and relational (e.g., parent–child interactions, parental mental health) dimensions that jointly influence neurodevelopmental trajectories. This narrative review examines how key domains of the family environment serve as protective factors or sources of vulnerability through their mutual interplay in shaping child neurodevelopment, with the aim of synthesizing current evidence and highlighting directions for early preventive and therapeutic interventions.

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Cite This Study

Loi et al. (2026) studied this question.

synapsesocial.com/papers/6a1bcfe15783ba022b6fbd1fhttps://doi.org/10.1016/j.gpeds.2026.100349
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