What does this research mean for the field?

Dietary DNA is absorbed in the intestine primarily as pyrimidine deoxyribonucleosides, with dinucleotides acting as a previously unrecognized absorption form. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the molecular forms of food-derived DNA absorbed in the small intestine of mice.

May 31, 2026Journal of Nutrition and MetabolismOpen Access

Characterization of Gastrointestinal Absorption of Salmon Milt‐Derived Oligodeoxyribonucleic Acids in Mice

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Authors

FHFuyu Hayashi YMYusuke Masuo YNYuki Nishizawa

Discussion

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Overview

Randomized trial characterizes dietary DNA absorption in mice, revealing key nucleic acid forms.

Key Points

To investigate the molecular forms of food-derived DNA absorbed in the small intestine of mice.
Administered hydrolyzed Oncorhynchus milt DNA (HD-omDNA), deoxyribonucleotides (dNTs), and deoxyribonucleosides (dNSs) to mice.
Utilized LC–MS/MS to quantify nucleic acid monomers that permeated the intestinal membrane.
Assessed intestinal permeation using the Ussing chamber method.
Pyrimidine dNSs, such as thymidine and deoxycytidine, were significantly increased in portal vein compared to controls.
Dinucleotides were detected in vivo, suggesting they are a recognized absorption form of dietary DNA.
Portal vein concentrations of hypoxanthine and xanthine increased upon co-administration with a xanthine oxidase inhibitor, confirming metabolism of purine monomers.

Cite This Study

Hayashi et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0525783ba022b6fc2b0 https://doi.org/10.1155/jnme/2183675

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May 31, 2026Journal of Nutrition and MetabolismOpen Access

Characterization of Gastrointestinal Absorption of Salmon Milt‐Derived Oligodeoxyribonucleic Acids in Mice

View Full Paper

Ask AI

Bookmark

Authors

FHFuyu Hayashi YMYusuke Masuo YNYuki Nishizawa

Discussion

Member takes

Overview

Randomized trial characterizes dietary DNA absorption in mice, revealing key nucleic acid forms.

Key Points

To investigate the molecular forms of food-derived DNA absorbed in the small intestine of mice.
Administered hydrolyzed Oncorhynchus milt DNA (HD-omDNA), deoxyribonucleotides (dNTs), and deoxyribonucleosides (dNSs) to mice.
Utilized LC–MS/MS to quantify nucleic acid monomers that permeated the intestinal membrane.
Assessed intestinal permeation using the Ussing chamber method.
Pyrimidine dNSs, such as thymidine and deoxycytidine, were significantly increased in portal vein compared to controls.
Dinucleotides were detected in vivo, suggesting they are a recognized absorption form of dietary DNA.
Portal vein concentrations of hypoxanthine and xanthine increased upon co-administration with a xanthine oxidase inhibitor, confirming metabolism of purine monomers.

Cite This Study

Hayashi et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0525783ba022b6fc2b0 https://doi.org/10.1155/jnme/2183675

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