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May 31, 2026Substance Use &amp Addiction Journal

Atomoxetine Versus Placebo for Cognitive Deficits in Stimulant Use Disorder: A Systematic Review

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Authors

DBDouglas BarrosoUniversidade Estadual de Santa CruzMKMartin KotochinskyUniversidad Nacional de CuyoMAMateus Rodrigues AlessiUniversidade Positivo

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Implication

Systematic review evaluates efficacy of atomoxetine for cognitive deficits in stimulant use disorder, suggesting limited benefits.

Key Points

  • This review aims to evaluate the efficacy of atomoxetine, a treatment for cognitive deficits in stimulant use disorder, compared to placebo.
  • Comprehensive literature search of PubMed, Cochrane CENTRAL, and Embase databases.
  • Included randomized controlled trials evaluating atomoxetine against placebo with outcomes on cognition, stimulant use, mood, and safety.
  • Data were qualitatively synthesized due to methodological heterogeneity.
  • Nine randomized controlled trials were included in the review.
  • Cognitive outcomes showed inconsistent improvements in attention and inhibitory control; some studies reported no significant effects.
  • Atomoxetine did not significantly reduce stimulant use or craving, with limited mood benefits observed.

Cite This Study

Barroso et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0525783ba022b6fc35ahttps://doi.org/10.1177/29767342261443842
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Also Consider

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  1. 1Drug Overdose Deaths Involving Stimulants ― United States, January 2018–June 20242025 · 41 citations
  2. 2Atomoxetine in the Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Dose-Response Study2001 · 670 citations
  3. 3Safety of Atomoxetine in Combination With Intravenous Cocaine in Cocaine-Experienced Participants2012 · 17 citations
  4. 4Psychostimulant drugs for cocaine dependence2016 · 109 citations