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May 31, 2026Annals of Surgical Oncology1 citationsOpen Access

The Evolution of Sentinel Lymph Node Biopsy in Breast Cancer Management

The Past, Present, and Future of Sentinel Lymph Node Biopsy in Breast Cancer

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Authors

MSMichael StanczykTCTiffany C. CheungJLJulie E. Lang

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Overview

Review outlines advances in Sentinel Lymph Node Biopsy, optimizing axillary staging in breast cancer.

Key Points

  • This review investigates the development and clinical applications of sentinel lymph node biopsy in breast cancer management.
  • Examined historical trials including NSABP B-32 and ALMANAC for SLNB outcomes.
  • Evaluated newer techniques such as dual-tracer mapping and targeted axillary dissection to enhance accuracy.
  • Explored ongoing trials and innovations in imaging-guided axillary staging.
  • SLNB shows comparable overall survival and disease-free survival compared to axillary lymph node dissection.
  • Omission of completion axillary lymph node dissection is supported for select patients with limited SLN metastases.
  • Technological advances have led to improved sentinel lymph node identification, reducing false-negative rates.

Cite This Study

Stanczyk et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0845783ba022b6fc564https://doi.org/10.1245/s10434-026-19672-4
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