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Comparative study evaluates urea-containing peptides for prostate cancer targeting, suggesting improved synthetic strategies.
Prostate-specific membrane antigen (PSMA) is a validated target for prostate cancer imaging and radiotherapy, with most high-affinity ligands incorporating the lysine–urea–glutamate (KuE) pharmacophore. Despite emerging triphosgene-free approaches, current synthetic strategies...
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Douglas et al. (2026) studied this question.
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