Chemical epigenetic modification uncovers new isocoumarins from the endophyte Dothideomycetes sp. BMC-101

Yajuan Cong; Haotian Wang; Hong Wang; Jing Jiang; Lanying Li; Runyu Wu; Yixuan Zhang; Qiang Huo; Meilin Zhu

doi:10.1039/d6ra02544g

January 1, 2026RSC AdvancesOpen Access

Chemical epigenetic modification uncovers new isocoumarins from the endophyte Dothideomycetes sp. BMC-101

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to discover novel isocoumarins from the endophyte Dothideomycetes sp. BMC-101 through chemical epigenetic modification.
Isolating four isocoumarins, including two enantiomer pairs and two analogs, from the endophyte Dothideomycetes sp. BMC-101.
Utilizing OSMAC (One Strain—Many Compounds) approach and MS/MS molecular networking for compound identification.
Isolated compounds include two enantiomer pairs: (±)-dothideomarins A (1a/1b) and B (2a/2b), along with two additional analogs C and D (3 and 4).

Implication

Study unveils new isocoumarins from an endophytic fungus, suggesting potential applications in biotechnology.

Abstract

Four isocoumarins, including two enantiomer pairs [(±)-dothideomarins A (1a/1b) and B ( 2a / 2b )] and two analogs C and D (3 and 4), were isolated from endophytic fungus Dothideomycetes sp. BMC-101 via OSMAC & MS/MS molecular networking.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Cong et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0b55783ba022b6fc623 https://doi.org/10.1039/d6ra02544g

View Full Paper

Ask AI

Bookmark

Share

Chemical epigenetic modification uncovers new isocoumarins from the endophyte Dothideomycetes sp. BMC-101

Key Points

Implication

Abstract

Discussion

Cite This Study

Chemical epigenetic modification uncovers new isocoumarins from the endophyte Dothideomycetes sp. BMC-101

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading