Hypertext systems have traditionally been constructed by hand. This process can stand improvement in several aspects: it is laborious; requires a human to understand the text and infer all the relationships between the concepts/topics; and while the resulting hypertext may be traversed by a reader in an arbitrary fashion, s/he may still find it difficult to understand the concepts as expressed by the builder of the hypertext.
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Clitherow et al. (1989) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: