Why the study?
Does prophylactic amiodarone reduce the rate of atrial fibrillation in patients undergoing coronary artery bypass surgery?
Population
192 patients undergoing coronary artery bypass grafting (myocardial revascularisation)
Comparison
Amiodarone infusion followed by oral amiodarone… vs Infusion of dextrose 5% solution followed by a…
Design
RCT, Randomized to either amiodarone or placebo, Matched regimen of placebo…
Follow-up
6 weeks
Authors
Loading...
Does not support routine prophylactic amiodarone post-CABG; challenges assumptions of benefit and guides alternative strategies in future trials.
Does prophylactic amiodarone reduce the rate of atrial fibrillation in patients undergoing coronary artery bypass surgery?
Prophylactic amiodarone did not significantly reduce the incidence of atrial fibrillation after coronary artery bypass surgery, although it did lower the maximum ventricular rate during AF episodes.
Harahsheh et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: