The Relationship between Antibody-mediated Immune Responses andFour Types of Neurodegenerative Diseases: A Mendelian RandomizationAnalysis

Introduction: Recognizing the risk factors associated with neurodegenerative diseases is essential for their prevention. Currently, no studies are exploring the causal link between antibody-mediated immune responses and neurodegenerative diseases. This Mendelian randomization (MR) study further examines whether a causal relationship exists between antibodymediated immune responses and neurodegenerative diseases, and offers evidence supporting causality. Method: Data on antibody-mediated immune responses came from this study, which selected 9,724 subjects as the subgroup research participants and collected their serum samples for microbiological serological analysis. The large artery atherosclerotic stroke data includes 4,373 patients. The multiple sclerosis consists of 1,683 cases. Parkinson's disease comprises 37,688 cases. Alzheimer's disease includes 17,008 cases. MR analysis was conducted to estimate the associations between antibody-mediated immune responses(exposure) and neurodegenerative diseases(outcome) risk Result: The IVW analysis revealed that 9 antibody-mediated immune responses were associated with 4 neurodegenerative diseases, including anti-varicella-zoster virus and Epstein-Barr virus antibodies, and others. Discussion: This study systematically investigates, for the first time through Mendelian randomization analysis, the potential relationships between antibody-mediated immune responses and various neurodegenerative diseases. The results indicate that a total of 9 antibody-mediated immune responses are significantly associated with the risk of four neurodegenerative diseases: Conclusion: These antibody-mediated immune responses serve as potential markers for predicting the occurrence and development of neurodegenerative diseases. Our genetic analysis suggests that antibodies against antigens may be involved in the pathological process of neurodegenerative diseases, which provides a new direction for future exploration of their specific mechanisms.