In patients with myocardial infarction, CRP levels ≥12 mg/L compared to <2.9 mg/L were associated with higher absolute risk of death at 0-30 days (9.7% vs 2.8%) and 31-365 days (9.5% vs 4.1%).
Cohort (n=29,035)
Yes
Do higher CRP concentrations measured within 24 hours of index hospitalization increase the risk of death and incident heart failure in patients with a first myocardial infarction?
Higher standard CRP concentrations measured within 24 hours of admission for a first myocardial infarction are associated with a stepwise increase in the risk of short- and long-term mortality and incident heart failure.
Absolute Event Rate: 9.7% vs 2.8%
Background and Aims The long-term prognostic value of standard C-reactive protein (CRP) in patients with myocardial infarction is unknown. Methods Using Danish nationwide registries, we identified patients with a first diagnosis of myocardial infarction from 2013 through 2020, who had a CRP measurement =12 mg/l. At 0-30 days, 1,660 patients had died, and 1,861 died between days 31-365. The standardized absolute risk of death at both 0-30 and 31-365 days was lowest among patients in quartile 1 (0-30 days: 2.8%, 31-365 days: 4.1%) and highest among patients in quartile 4 (0-30 days: 9.7%, 31-365 days: 9.5%). The standardized relative risks of death increased in a stepwise fashion from quartile 2 to quartile 4 when using quartile 1 as the comparator. Similar findings were observed for heart failure. Conclusion Among patients with myocardial infarction, higher CRP concentrations were significantly associated with a higher risk of death and incident heart failure.
Borchsenius et al. (Fri,) conducted a cohort in myocardial infarction (n=29,035). Higher C-reactive protein (CRP) concentrations (quartile 4) vs. Lower CRP concentrations (quartile 1) was evaluated on death from any cause. In patients with myocardial infarction, CRP levels ≥12 mg/L compared to <2.9 mg/L were associated with higher absolute risk of death at 0-30 days (9.7% vs 2.8%) and 31-365 days (9.5% vs 4.1%).