Introduction: Wound healing is a complex biological process that involves tissue repair and the restoration of skin integrity. Natural oils have gained increasing attention for their bioactive components, which may accelerate wound healing. This study explores the therapeutic potential of selected natural oils known for their antibacterial, anti-inflammatory, and collagen-stimulating properties. Methods: A qualitative literature review was conducted using data from peer-reviewed journals focusing on the roles of jojoba, rosehip, calendula, lavender, cod-liver, crocodile, and sesame oils in wound healing. Emphasis was placed on their biochemical compositions, mechanisms of action, and clinical relevance in wound care. Results: The oils evaluated exhibit beneficial properties conducive to wound healing. Jojoba oil mimics skin sebum, forming a hydrating and protective layer. Rosehip oil, rich in essential fatty acids and vitamins A and C, enhances collagen synthesis and skin elasticity. Calendula oil demonstrates strong anti-inflammatory and antifungal activity, promoting granulation tissue. Lavender oil contributes antimicrobial effects and facilitates faster wound closure. Sesame oil contains potent antioxidants that mitigate oxidative stress and support tissue regeneration. Discussion: These oils play a multifaceted role in wound care by maintaining a moist environment, promoting tissue repair, and potentially improving cosmetic outcomes, such as minimizing scars. Their diverse mechanisms—ranging from anti-infective action to antioxidant defense—- make them suitable for incorporation into topical formulations, ointments, and modern wound dressings. Conclusion: Natural oils represent promising adjuncts in wound healing strategies, combining efficacy with biocompatibility. Further clinical trials are essential to standardize their usage and optimize their integration into evidence-based wound management practices. However, despite promising preclinical and limited clinical findings, the absence of robust, large-scale randomized clinical trials restricts definitive conclusions regarding efficacy and optimal use. Further well-designed human studies are essential to validate their therapeutic potential and establish standardized wound care protocols.
Komal et al. (Thu,) studied this question.