Key result
Platelet reactivity shows a U-shaped association with cardiovascular mortality in CAD patients.
Why the study?
The relationship between platelet reactivity measured as PRU and cardiovascular mortality in CAD remains incompletely characterized, particularly regarding potential non-linear associations.
Is there a non-linear association between platelet reactivity (PRU) and cardiovascular mortality in patients with CAD?
Population
1000 patients with angiographically confirmed CAD treated at a tertiary cardiology center in Kazakhstan
Comparison
Varying platelet reactivity levels measured as PRU
Design
Retrospective observational cohort study
Authors
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Non-linear PRU-CV mortality link in CAD may exist; leaves open whether PRU-guided adjustment improves outcomes.
Cohort (n=1,000)
No
Is there a non-linear association between platelet reactivity (PRU) and cardiovascular mortality in patients with CAD?
Effect estimate: OR ~1.00
p-value: p=> 0.05
A U-shaped relationship exists between platelet reactivity and cardiovascular mortality in CAD patients, indicating that both insufficient and excessive platelet inhibition confer increased risk.
Жангелова et al. (2026) conducted a cohort in Coronary artery disease (n=1,000). Platelet reactivity (PRU) was evaluated on Cardiovascular mortality (OR ~1.00, p=> 0.05). Platelet reactivity (PRU) exhibited a significant U-shaped association with cardiovascular mortality in CAD patients, whereas conventional linear models showed no association (OR ~1.00; p>0.05).
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