Elevated Plasma Fibrinogen Rather Than Residual Platelet Reactivity After Clopidogrel Pre-Treatment Is Associated With an Increased Ischemic Risk During Elective Percutaneous Coronary Intervention

“I am not prepared to accept that a platelet count over 400,000 would make no contribution, even if many of the PCI related infarcts are within a range of 150-300,000. I don't know how much power there is in the discussion. The role of tissue factor (plaque), and of platelets in hemostasis is undeniable.”

“How ironic that an old diagnostic parameter should reappear in the limelight of diagnostic predictors. Of course, decades ago, doctors asked for 'sed rates', seeking to know if red cells, thought to be bound to fibrinogen, settled faster in a patient compared to a control subject's blood. Fibrinogen has always been a diagnostic number in evaluating inflammatory results.”