Polysaccharide PSLP-1 from Polygonatum sibiricum Stems and Leaves Alleviates Depressive-like Behaviors and Modulates Gut Microbiota and Tryptophan Metabolism along the Gut–Brain Axis

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This study aims to characterize the polysaccharide PSLP-1 from Polygonatum sibiricum and evaluate its effects on depressive-like behaviors and metabolic pathways.
PSLP-1 was isolated from Polygonatum sibiricum stems and leaves and analyzed for structural characteristics.
A chronic restraint stress mouse model was employed to assess antidepressant-like effects through forced swim and tail suspension tests.
Changes in tryptophan metabolism and gut microbiota were evaluated post-treatment with PSLP-1.
PSLP-1 significantly reduced immobility time in the forced swim test (p<0.05) and tail suspension test (p<0.01).
It restored tryptophan metabolism by reducing indoleamine 2,3-dioxygenase 1 activity (effect size not quantified) and increasing 5-hydroxytryptamine levels.
Gut microbiota analysis revealed increased Akkermansia and decreased Lactobacillus and Alistipes after PSLP-1 treatment.

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Shows PSLP-1 alleviates depressive-like behaviors in mice, highlighting its potential as a therapeutic agent.

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Huang et al. (2026) studied this question.

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