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January 20, 2021Frontiers in PhysiologyOpen Access

Noiseless Variable-Pressure Neck Chamber Device to Assess the Carotid Baroreflex Function

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Why the study?

Use of the variable-pressure neck chamber technique in hospital environments is limited by loud noise emitted during operation.

Does a newly developed noiseless neck chamber device effectively assess carotid baroreflex function and operate with lower noise compared to a regular system in healthy participants?

Population

Six healthy, young, asymptomatic participants

Comparison

Suction of -60 mmHg for 5 s using a novel noiseless neck suction chamber device

Authors

APAlessandro PinheiroIscte – Instituto Universitário de LisboaLVLauro C. ViannaPreventive CardiologyJCJake Carvalho do CarmoUniversidade de Brasília

Discussion

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Implication

May enable quieter clinical baroreflex testing; hypothesis-generating and leaves adoption open pending larger trials.

Key Points

  • To develop and evaluate a noiseless, variable-pressure neck chamber device capable of stimulating human carotid sinus baroreceptors without the disruptive acoustic noise of conventional equipment.
  • Engineered a non-invasive, 3D-printed anatomical neck suction chamber regulated by a microcontroller and computer interface.
  • Evaluated the device on six healthy, normotensive adults (five men; mean age 32 ± 6 years) who abstained from caffeine, alcohol, and strenuous exercise for 12–24 hours.
  • Delivered a negative pressure stimulus of −60 mmHg for 5 seconds while recording cardiovascular metrics and operating noise levels.
  • Neck suction consistently induced reflex bradycardia of −10 ± 2 bpm and a depressor response of −15 ± 4 mmHg across all trials.
  • The custom neck chamber operated at a sound pressure level of 34.3 dB, compared to 74.6 dB generated by standard vacuum-cleaner-based systems.

Structured PICO

Does a newly developed noiseless neck chamber device effectively assess carotid baroreflex function and operate with lower noise compared to a regular system in healthy participants?

P
Population
6 healthy, young, asymptomatic participants (five men; 32 ± 6 year), normotensive, nonsmoking, in sinus rhythm, free of known cardiovascular or metabolic diseases, and not consuming any acute or chronic medications.
I
Intervention
Noiseless neck suction chamber device (NCD) applying a suction of -60 mmHg for 5 s.
C
Comparator
Regular vacuum-cleaner-based system (for noise comparison).
O
Outcome
Blood pressure and heart rate responses to neck suction, and device sound pressure level (SPL).surrogate

A novel noiseless neck chamber device effectively assesses carotid baroreflex function with significantly reduced noise, facilitating its potential use in clinical settings.

Cite This Study

Pinheiro et al. (2021) studied this question.

synapsesocial.com/papers/6a1bd1ec0a1f7575939cfe2ahttps://doi.org/10.3389/fphys.2020.613311
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recent Insights into Carotid Baroreflex Function in Humans Using the Variable Pressure Neck Chamber2003 · 127 citations
  2. 2The Variable-Pressure Neck-Chamber Method for Studying the Carotid Baroreflex in Man1977 · 134 citations
  3. 3Baroreflex inhibition of the human sinus node: importance of stimulus intensity, duration, and rate of pressure change.1977 · 97 citations
  4. 4Impaired carotid baroreflex control of arterial blood pressure in multiple sclerosis2016 · 26 citations
  5. 5Adaptation of the human carotid baroreceptor‐cardiac reflex.1977 · 57 citations