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The Effect of Dexmedetomidine on Postoperative Acute Kidney Injury in High-Risk Partial Nephrectomy Patients: A Retrospective Cohort Study

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This study aims to evaluate the effect of dexmedetomidine on postoperative acute kidney injury in high-risk patients undergoing partial nephrectomy.
Single-center retrospective cohort study conducted from 2015 to 2023.
Included high-risk patients with solitary kidney or pre-existing chronic kidney disease.
Patients were divided into dexmedetomidine-exposed and non-exposed groups, with inverse probability of treatment weighting applied.
Adjusted analysis showed dexmedetomidine exposure reduced AKI incidence to 23.9% versus 38.6%, P = 0.025.
Intraoperative urine output was higher in the dexmedetomidine group (341 ± 183 mL) compared to the non-exposed group (282 ± 188 mL), P = 0.022.
No significant differences in postoperative hospital stay, complications, or long-term renal function outcomes were observed.

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Retrospective cohort study shows dexmedetomidine reduces AKI in high-risk patients, suggesting potential benefits.

Zhang et al. (2026) studied this question.

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