What does this research mean for the field?

Older men with silent myocardial ischemia exhibit reduced HDL-C and HDL2 subspecies levels, which appear to be driven by elevated hepatic lipase activity rather than differences in abdominal obesity or hyperinsulinemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1992Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia.

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Why the study?

Do older men with silent myocardial ischemia have altered lipid profiles and hepatic lipase activity compared to normal controls?

Population

65 apparently healthy nonsmoking, nondiabetic older men with normal plasma cholesterol levels, including 18…

Design

Case-control

Authors

LKLeslie I. KatzelGeneral / Preventive / Lipids PCPatricia J. CoonBillings Clinic MBM. Janette BusbyNational Institutes of Health

Discussion

Member takes

Implication

Associates higher hepatic lipase with dyslipidemia in silent ischemia; leaves open causality and clinical relevance in older men.

Structured PICO

Do older men with silent myocardial ischemia have altered lipid profiles and hepatic lipase activity compared to normal controls?

Population

65 apparently healthy nonsmoking, nondiabetic older men (mean age 60 +/- 7 years) with normal plasma cholesterol levels, including 18 with silent myocardial ischemia (SI) and 47 normal control subjects.

Comparator

Normal control subjects of similar age, obesity, and maximal aerobic capacity

Outcome

Plasma levels of high density lipoprotein (HDL), HDL2 subspecies, and postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activitiessurrogate

In older men with silent myocardial ischemia, reduced HDL-C levels and elevated triglycerides may be related to elevations in hepatic lipase activity, predisposing them to atherosclerosis despite normal total cholesterol.

Cite This Study

Katzel et al. (1992) studied this question.

synapsesocial.com/papers/6a1bd2235b8f4ede65a91aca https://doi.org/10.1161/01.atv.12.7.814

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Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider