High‐Entropy Alloys: Founding Concepts and Pathways for Biomedical Future Development

Studies on the use of high‐entropy alloys (HEAs) as biomedical implants have increased tremendously because of their superior mechanical strength, corrosion resistance and biocompatibility. HEAs are contrasted to the traditional alloys, which are formed on one main element, and consist of more than one main element in approximately equal proportions, forming stable solid‐solution microstructures with multifunctional characteristics. The given review is dedicated to the methods of the material selection of biomedical grade HEAs with a particular emphasis on the interconnection between the elemental composition and the processing methods, such as additive manufacturing and surface modification, and the biological response. Ti‐, Zr‐, Nb‐, Ta‐ and Hf‐based systems are the same as the HEA families that have been shown to be more compatible with the bone tissue, less cytotoxic and corrosive resistance when exposed to physiological conditions. The research also points to the fact that translating HEAs used in laboratory research to reliable orthopaedic and dental implants is achievable through the use of computational design, experimental validation and optimization in the production of next‐generation biomaterials, which can fulfil the requirements of mechanical and clinical performance.