A-D-A structured phototheranostics for NIR fluorescence imaging guided Type I/II photodynamic and photothermal therapy of tumor

Xinyu Wang; Houxian He; Yunquan Yang; Qingxu Diao; Mingqin Xiong; Minhuan Lan; Dayong Xu; Shaojing Zhao; Yuanyu Tang; Pang E; Jianing Yi

doi:10.1039/d6nr00172f

January 1, 2026Nanoscale

A-D-A structured phototheranostics for NIR fluorescence imaging guided Type I/II photodynamic and photothermal therapy of tumor

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Key Points

The aim is to develop a single-component nanotheranostic platform for enhanced tumor imaging and therapy.
Utilized 4TIC nanoparticles formed through molecular self-assembly.
Applied single-wavelength (808 nm) laser irradiation for therapy.
Conducted experiments to evaluate the effectiveness of fluorescence imaging and phototherapy.
4TIC nanoparticles effectively improved tumor targeting and imaging.
Significantly enhanced therapeutic effects observed in treated groups compared to controls.
NIR fluorescence imaging allowed precise monitoring of treatment response.

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Implication

Demonstrates effective tumor treatment in guided phototherapy, suggesting a new therapeutic option.

Abstract

Here we report a compact, single-component nanotheranostic platform—4TIC nanoparticles—formed by molecular self-assembly of an A-D-A-structured near infrared (NIR) photosensitizer (4TIC) and DSPE-PEG-NH₂. Upon single-wavelength (808 nm) laser irradiation, 4TIC NPs...

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Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2515783ba022b6fdbe2 https://doi.org/10.1039/d6nr00172f

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A-D-A structured phototheranostics for NIR fluorescence imaging guided Type I/II photodynamic and photothermal therapy of tumor

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A-D-A structured phototheranostics for NIR fluorescence imaging guided Type I/II photodynamic and photothermal therapy of tumor

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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