Rheumatoid Arthritis Flare as a System-Level Transition: Integrating Cellular, Physiological, Behavioral, and Predictive Evidence into a Dynamical Framework. Conceptual Note — URM Series.

Description This conceptual note develops a Universal Resonance Model (URM) interpretation of rheumatoid arthritis flare as a system-level transition rather than an isolated clinical event. The paper integrates evidence from cellular and molecular studies, wearable sensor data, smartphone-derived behavioral signals, and machine learning–based longitudinal prediction models. Together, these layers suggest that RA flare may be preceded by measurable changes in immune activity, physiological regulation, behavior, and temporal disease structure. The note proposes that flare prediction is possible because flare is preceded by system-level dynamical change. It does not replace established immunological or clinical explanations of rheumatoid arthritis, but adds a dynamic interpretive layer for understanding flare as the observable endpoint of prior transition dynamics. This work is conceptual and does not introduce new clinical data or clinical recommendations.