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May 31, 20260 citationsOpen Access

HPLC Method Development and Validation for Ursolic Acid and Mometasone Furoate

High -Performance Liquid Chromatography Method for the Method Development of Ursolic Acid and Mometason Furoate: Development and Validation

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Authors

RYRahul Dubey Neetu Yadav*

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Overview

Randomized trial evaluates a new HPLC method for estimating Ursolic Acid and Mometasone Furoate in pharmaceuticals, indicating its reliability.

Key Points

  • This research aims to develop and validate an HPLC method for the quantitative analysis of Ursolic Acid and Mometasone Furoate.
  • Developed HPLC method using a C18 column and varying mobile-phase compositions.
  • Optimized conditions: methanol:water (60:40, v/v), flow rate 1.0 mL/min, detection at 296 nm, 40°C column temperature, total run time 5 min.
  • Evaluated method for linearity, accuracy, precision, and applicability to marketed formulations.
  • Calibration showed peak area increased proportionally for Mometasone Furoate (10-60 ug/mL) and Ursolic Acid (5-30 ug/mL).
  • Recovery values for both analytes were close to 100%, with %RSD values below 1%.
  • Assay values for Cystone and Yam Balance preparations were close to label claims.

Cite This Study

Rahul Dubey Neetu Yadav* (2026) studied this question.

synapsesocial.com/papers/6a1bd2675783ba022b6fdec0https://doi.org/10.5281/zenodo.20442824
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