What does this research mean for the field?

The Abbott Architect STAT Troponin-I assay provides highly sensitive measurement of cardiac troponin I with a 10% coefficient of variation near the 99th percentile reference limit, but is susceptible to positive interference from heterophile antibodies. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 31, 2006Clinical Chemistry

Performance Evaluation and Subsequent Clinical Experience with the Abbott Automated Architect STAT Troponin-I Assay

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Why the study?

Does the Architect STAT Troponin-I assay provide precise and sensitive measurement of cardiac troponin I compared to other assays?

Population

480 healthy blood donors (reference population) and 339 samples from hospital patients

Comparison

Architect STAT Troponin-I assay vs AxSYM first-generation cTnI and Access…

Authors

QLQue LamAlfred Health MBMarion BlackSan Francisco VA Medical Center OYOdette YoudellThe Alfred Hospital

Discussion

Member takes

Implication

Supports sensitive low-level cTnI detection with Architect STAT; leaves open clinical impact of heterophile interference.

Structured PICO

Does the Architect STAT Troponin-I assay provide precise and sensitive measurement of cardiac troponin I compared to other assays?

Population

480 healthy blood donors (reference population) and 339 samples from hospital patients

Intervention

Architect STAT Troponin-I assay (Abbott Diagnostics)

Comparator

AxSYM first-generation cTnI (Abbott Diagnostics) and Access second-generation AccuTnI (Beckman Coulter) assays

Outcome

Analytical performance including precision (CV), correlation with other assays, and occurrence of heterophile antibody interferencesurrogate

The Architect STAT Troponin-I assay provides highly sensitive and precise measurement of cTnI at low concentrations, though clinicians must be aware of potential heterophile antibody interference.

Cite This Study

Lam et al. (2006) studied this question.

synapsesocial.com/papers/6a1bd278ea84844e355f076a https://doi.org/10.1373/clinchem.2005.057216

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Performance Evaluation and Subsequent Clinical Experience with the Abbott Automated Architect STAT Troponin-I Assay

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Performance Evaluation and Subsequent Clinical Experience with the Abbott Automated Architect STAT Troponin-I Assay

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider