What does this research mean for the field?

Cardiopulmonary support in children with fulminant myocarditis can be safely maintained without circuit exchange and discontinued before bleeding becomes symptomatic, guided by improvements in biomarkers and mixed venous blood oxygen saturation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2007Circulation JournalOpen Access

Recommendations for Weaning off Cardiopulmonary Support in Children With Fulminant Myocarditis

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Why the study?

What are the appropriate clinical and biomarker indicators for weaning off cardiopulmonary support in children with fulminant myocarditis?

Population

4 children with fulminant myocarditis treated with cardiopulmonary support (CPS), mean age 9 years.

Design

Case_series

Authors

HKHiroshi KanamaruNihon University KKKensuke KarasawaTokyo Women's Medical University OAOsamu AbeShiga University of Medical Science

Discussion

Member takes

Implication

SvO2 and biomarker trends may guide CPS weaning in pediatric fulminant myocarditis; leaves open prospective validation before practice change.

Structured PICO

What are the appropriate clinical and biomarker indicators for weaning off cardiopulmonary support in children with fulminant myocarditis?

Population

4 children with fulminant myocarditis treated with cardiopulmonary support (CPS), mean age 9 years.

Intervention

Weaning off cardiopulmonary support (CPS)

Outcome

Relationships between timing of weaning from CPS and bleeding episodes, platelet count, serum CK-MB, echocardiographic findings, and mixed venous blood oxygen saturation (SvO2)surrogate

In children with fulminant myocarditis, CPS can be safely discontinued based on improvements in biomarkers and SvO2 before bleeding episodes become symptomatic.

Cite This Study

Kanamaru et al. (2007) studied this question.

synapsesocial.com/papers/6a1bd2fdd54006be995f0fa5 https://doi.org/10.1253/circj.71.1551

Topics

Myocarditis

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Implication

SvO2 and biomarker trends may guide CPS weaning in pediatric fulminant myocarditis; leaves open prospective validation before practice change.

Recommendations for Weaning off Cardiopulmonary Support in Children With Fulminant Myocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Recommendations for Weaning off Cardiopulmonary Support in Children With Fulminant Myocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider