Why the study?
Does blockade of the renin-angiotensin system improve endothelial dysbalance in diabetic nephropathy?
Does blockade of the renin-angiotensin system improve endothelial dysbalance in diabetic nephropathy?
This review highlights the role of endothelial dysfunction in diabetic nephropathy and the potential therapeutic benefit of renin-angiotensin system blockade in restoring endothelial balance.
RAS blockade may aid endothelial balance in diabetic nephropathy; leaves open need for trials to confirm renal benefit.
In recent years endothelial function has been forwarded a modulator in the pathogenesis of diabetic nephropathy. This review summarizes how an imbalance between endothelium-derived reactive nitrogen species and reactive oxygen species as well as increased expression of the endothelium-derived peptide endothelin-1 may contribute to loss of renal function in diabetes. In addition, the potentially beneficial effects of blockade of the renin-angiotensin system on this endothelial dysbalance is discussed.
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Rabelink et al. (1998) studied this question.
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