Why the study?
Heart failure models are typically based on clinical observations and are not consistently predictive, prompting a combined fluid dynamics and solid mechanics approach to uncover flow-tissue interplay anticipating heart failure.
A combined fluid dynamics and solid mechanics modeling approach provides a physics-based explanation for clinical outcomes in children with a surgically transformed single right ventricle.
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Supports physics-based modeling of single right ventricle outcomes; leaves open prospective validation before clinical use.
Heart failure is a progressive pathology that represents the main life-threatening cardiac disease. Its models are typically based on clinical observations and are not consistently predictive. This study employs an approach based on both fluid dynamics and solid mechanics to uncover the flow-tissue interplay that may anticipate the development of heart failure. The physiological fluid-structure interaction is analyzed in children with a single right ventricle (SRV), where the right ventricle has been surgically transformed to take on the role of an underdeveloped left ventricle. The results provide a physics-based explanation for the observed clinical outcome in these patients.
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Collia et al. (2023) studied this question.
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