Key result
Pre-procedural bleeding history is linked to lower MACE risk after lower extremity revascularization.
Why the study?
Patients with peripheral artery disease undergoing lower extremity revascularization remain at high risk for cardiovascular events despite intervention.
Is significant pre-procedural bleeding history associated with a lower risk of cardiovascular events in patients with peripheral artery disease undergoing lower extremity revascularization?
Cohort
Is significant pre-procedural bleeding history associated with a lower risk of cardiovascular events in patients with peripheral artery disease undergoing lower extremity revascularization?
A significant pre-procedural bleeding history is paradoxically associated with a lower risk of major adverse cardiovascular events and mortality following lower extremity revascularization.
Bleeding history may identify lower-risk PAD revascularization patients; hypothesis-generating and should not change practice.
Patients with peripheral artery disease undergoing lower extremity revascularization remain at high risk for cardiovascular events despite intervention. This retrospective analysis of 289 participants examined the relationship between pre-procedural bleeding history and post-procedural outcomes using a modified International Society on Thrombosis and Haemostasis bleeding assessment tool. After median 18-month follow-up, participants with significant bleeding history experienced lower risk of major adverse cardiovascular events (18.4% versus 30.6%, p = 0.034) and mortality (13.6% versus 24.2%, p = 0.047). An inverse exposure-outcome relationship was observed between bleeding severity and outcomes. Bleeding history may identify patients at lower risk for thrombotic complications. Graphical abstract Methods and key findings
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Bresnahan et al. (2026) conducted a cohort in Lower extremity revascularization. Bleeding history vs. No bleeding history was evaluated on Cardiovascular events. Bleeding history is associated with a lower risk of cardiovascular events in a cohort undergoing lower extremity revascularization.
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