October 6, 2009Circulation
Bleeding Increases the Risk of Ischemic Events in Patients With Peripheral Arterial Disease
Why the study?
Does major bleeding increase the risk of subsequent ischemic events in patients with peripheral arterial disease?
Population
2,650 patients with peripheral arterial disease after infrainguinal bypass surgery from the Dutch Bypass and…
Comparison
Major bleeding vs No major bleeding
Design
Cohort
Follow-up
mean 14 months
Authors
Discussion
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Member takes
Implication
May flag heightened ischemic risk after major bleeding in PAD; hypothesis-generating and should not yet change practice.
Structured PICO
Does major bleeding increase the risk of subsequent ischemic events in patients with peripheral arterial disease?
P
Population
2,650 patients with peripheral arterial disease after infrainguinal bypass surgery from the Dutch Bypass and Oral Anticoagulants or Aspirin (BOA) Study
I
Intervention
Major bleeding (evaluated as an independent predictor/exposure)
C
Comparator
No major bleeding
O
Outcome
Composite of nonfatal myocardial infarction, nonfatal ischemic stroke, major amputation, and cardiovascular deathcomposite
In patients with peripheral arterial disease, major bleeding is independently associated with a significantly increased risk of subsequent major ischemic complications.
Cite This Study
Hattum et al. (2009) studied this question.