Why the study?
Prior studies suggested an association between atrial septal aneurysm (ASA) and fetal arrhythmias; this study aimed to assess that association and evaluate potential changes in cardiac output and aortic arch flow in a large cohort.
Does a higher atrial septal excursion index (ASEI) correlate with the incidence of fetal arrhythmias and hemodynamic changes in fetuses with isolated atrial septal aneurysm?
Population
147 fetuses diagnosed with isolated ASA and a structurally normal heart
Comparison
Fetuses with arrhythmias vs fetuses without arrhythmias
Design
Single-center retrospective study
Key result
In fetuses with isolated atrial septal aneurysm, a higher atrial septal excursion index was significantly associated with the presence of arrhythmias (median ASEI 0.79 vs 0.69; p<0.001).
Authors
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May flag arrhythmia risk in fetal atrial septal aneurysm with ASEI ≥0.74; leaves open prospective validation before monitoring changes.
Cohort (n=147)
No
Does a higher atrial septal excursion index (ASEI) correlate with the incidence of fetal arrhythmias and hemodynamic changes in fetuses with isolated atrial septal aneurysm?
p-value: p=<0.001
In fetuses with isolated atrial septal aneurysm, a higher atrial septal excursion index (≥0.74) is significantly associated with an increased risk of fetal arrhythmias, though not with significant hemodynamic changes.
Maximo et al. (2026) conducted a cohort in Isolated atrial septal aneurysm (n=147). Higher atrial septal excursion index (ASEI) vs. Lower ASEI was evaluated on Presence of arrhythmias (p=<0.001). In fetuses with isolated atrial septal aneurysm, a higher atrial septal excursion index was significantly associated with the presence of arrhythmias (median ASEI 0.79 vs 0.69; p<0.001).